Synthesis and Characterization of Schiff Bases of Aminothiazolylbromo Coumarin for Their Analgesic and Anti-inflammatory Activity

Abstract

Some of the Schiff bases of aminothiazolylbromocoumarin are synthesized by the reaction between 2´- amino-4´-(6-bromo-3-coumarinyl) thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-bromocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for analgesic and anti-inflammatory activity by acetic acid-induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Some of the compounds have shown interesting biological activity based on the presence of certain functional groups.