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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Identification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy

https://doi.org/10.14233/ajchem.2020.22665
M. Chandra Sekhara Rao
1 Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India 2 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515002, India.
R. Chenna Krishna Reddy
2 Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515002, India. 3 Department of Science and Humanities, Sri Venkateswara College of Engineering, Karakambadi Road, Tirupati-517507, India
K.B. Chandra Sekhar
Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515002, India
Y.V. Rami Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

Corresponding Author(s) : Y.V. Rami Reddy

dryvrsvu@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

A simple FT-Raman spectroscopic method was developed for identification of finasteride polymorph form in finished dosage form. Finasteride polymorph form I was used in the tablet preparation and the weight fraction of finasteride in tablet was only about 0.023. The method was successfully used to identify the polymorphic form of finasteride in tablet and also to detect up to a level of about 15% of the other polymorph of finasteride present in the solid dosage. The dosage form was characterized by different techniques i.e. powdered X-ray diffraction, infrared spectroscopy and Raman spectroscopy. Based on literature survey, only Raman spectroscopy method is able to identify the polymorph of finasteride in dosage form.

Keywords

Identification FT-Raman spectroscopy Polymorphs Finasteride
Sekhara Rao, M. C. ., Krishna Reddy, R. C. ., Chandra Sekhar, K. ., & Rami Reddy, Y. . (2020). Identification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy. Asian Journal of Chemistry, 32(8), 1865–1868. https://doi.org/10.14233/ajchem.2020.22665
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References
  1. S.G. Antonio, C.O. Paiva-Santos and V.D.N. Bezzon, J. Pharm. Sci., 103, 3567 (2014); https://doi.org/10.1002/jps.24148
  2. L.M. da Silva, C.M. Montanari, O.M.M. Santos, E.C.L. Cazedey, M.L. Ângelo and M.B. de Araújo, J. Pharm. Biomed. Anal., 105, 24 (2015); https://doi.org/10.1016/j.jpba.2014.11.045
  3. A. Othman, J.S.O. Evans, I.R. Evans, R.K. Harris and P. Hodgkinson, J. Pharm. Sci., 96, 1380 (2007); https://doi.org/10.1002/jps.20940
  4. I. Wawrzycka, K. Stpniak, S. Matyjaszczyk, A.E. Kozio³, T. Lis and K.A. Abboud, J. Mol. Struct., 474, 157 (1999); https://doi.org/10.1016/S0022-2860(98)00569-9
  5. J.P. Higgins, S.M. Arrivo and R.A. Reed, J. Pharm. Sci., 92, 2303 (2003); https://doi.org/10.1002/jps.10465
  6. N.V. Phadnis, R.K. Cavatur and R. Suryanarayanan, J. Pharm. Biomed. Anal., 15, 929 (1997); https://doi.org/10.1016/S0731-7085(96)01939-5
  7. R. Suryanarayanan and C.S. Herman, Int. J. Pharm., 77, 287 (1991); https://doi.org/10.1016/0378-5173(91)90329-M
  8. J.A. McCauley, ALChE Symposium Series, 87, 58 (1991).
  9. Y. Tozuka, A. Ito, H. Seki, T. Oguchi and K. Yamamoto, Chem. Pharm. Bull., 50, 1128 (2002); https://doi.org/10.1248/cpb.50.1128
  10. K. Egusa, F. Okazaki, J. Schiewe, U. Werthmann and M. Wolkenhauer, Drugs R D, 17, 413 (2017); https://doi.org/10.1007/s40268-017-0196-6
  11. K.J. Booy, P. Wiegerinck, J. Vader, F. Kaspersen, D. Lambregts, H. Vromans and E. Kellenbach, J. Pharm. Sci., 94, 458 (2005); https://doi.org/10.1002/jps.20236
  12. A.M. Amado, M.M. Nolasco and P.J.A. Ribeiro-Claro, J. Pharm. Sci., 96, 1366 (2007); https://doi.org/10.1002/jps.20923
  13. L.S. Taylor and F.W. Langkilde, J. Pharm. Sci., 89, 1342 (2000); https://doi.org/10.1002/1520-6017(200010)89:10<1342::AID-JPS12>3.0.CO;2-X
  14. U.H. Doling, J.A. McCauley and R.J. Varsolona, Finasteride Processes, US Patent 5886184A (1997).
  15. M.C. Sekhara Rao, R.C.K. Reddy, K.B. Chandra Sekhar and Y.V.R. Reddy, Asian J. Chem., 29, 1735 (2017); https://doi.org/10.14233/ajchem.2017.20600
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