Synthesis, Structure Elucidation and Antimicrobial Activity of N-substituted α-Benzamido-β-[3-Methoxy-4-(p-Toluene Sulfonyloxy)]-Cinnamamides.

Abstract

3-Methoxy-4-(p-toluene sulfonyloxy)-benzaldehyde was condensed
with acylglycine in presence of sodium acetate and catalytic
amount of acetic anhydride yielded 2-phenyl-4-[3-methoxy-4-(ptoluenesulfonyloxy)-
benzylidene]-5-oxazolone. This compound on
reaction with hydrazine hydrate,  ammonia and different primary
amines yielded N-substituted  α-benzamido-β-[3-methoxy-4-(p-toluenesulfonyloxy)] cinnamohydrazidelcinnamamides. The newly
synthesised azalactone derivatives were characterized by their physical
properties,  elemental and spectral analysis.  All these compounds
were Screened for their antimicrobial activity against  E. coli,
Klebsiella, Staphylococci and Diplococci.