Synthesis of 2-N-Acylamino-4-Arylthiazole-5-Acetic acids/esters for Their Anti-inflammatory and Analgesic Activities

Abstract

Condensation of thiourea with 3-bromo-3-aryl propionates yielded 2-amino-4-aryl thiazole-5-acetates (3a–c). The compounds (3a–c) were hydrolyzed to thiazole-5-acetic acids (3d–f). The esters (3a–c) and acids (3d–f) were subjected to acylation with acetic anhydride and succinic
anhydride to give the title compounds (4a–d and 5a–f). Arti-inflammatory
and analgesic activities of some compounds have been evaluated.