Extractive Spectrophotometric Determination of Pioglitazone Hydrochloride Using Both Acidic and Basic Dyes

Abstract

Four simple extractive spectrophotometric methods have been developed for the estimation of Pioglitazone hydrochloride in pure and pharmaceutical dosage forms. These methods are based on the formation of ion association complexes of the drug with tropaeolin-OOO or woolfast blue or saffranin-O or methylene blue; the complexes were extracted with chloroform and the absorbances of the
chloroform layer were measured at 487 nm, 590 nm, 520 nm and
650 nm respectively. These methods have been statistically evaluated
and are found to be precise and accurate.