Synthesis of Some Novel 1,2,4-Dithiazolidines and Their Antibacterial and Antifungal Activity

Abstract

3-Naphthylimino-4-aryl/alkyl-5-phenylimino-1,2,4-dithiazolidines (Va–g) have been obtained by the basification of 3-naphthylimino-4-aryl/alkyl-5-phenylimino-1,2,4-dithiazolidine hydrochlorides (IVa–g). The latter were synthesized by the interaction of N-phenyl-S-chloro isothiocarbamoyl chloride (III) and 1-naphthyl- 3-aryl/alkyl thiocarbamides (IIa–g), which were prepared initially by the condensation of aryl/alkyl isothiocyanates (Ia–g) and 1-naphthylamine. The title compounds were assayed for their antibacterial and antifungal activity against gram-positive as well as gram-negative microorganisms such as E. coli, S. aureus, S. typhi, B. subtilis, A. aerogenes and A. niger.