Application of Hydrotropic Solubilization Technique for Quantitative Determination of Aspirin

Abstract

In the present investigation, 10 M urea solution has been employed to solubilize a poorly water-soluble drug, aspirin for its titrimetric analysis in tablets. Results of analysis by proposed methods were very comparable with those of a standard, British Pharmacopoeial method. Results of analysis have been validated statistically. The proposed method is quicker than pharmacopoeial method, new, rapid, simple, accurate and reproducible.