QSAR Study of N-[3-(1,1,2,2-Tetrafluoroethoxy)benzyl]-N- (3-phenoxyphenyl)trifluoro-3-amino-2-propanol Derivatives as Antiatherogenic Agents

Abstract

Coronary heart disease is one of the dreaded diseases prevailing now a day, which can be treated by the use of more potent and selective agents. One of such agent is Cholesterol ester transfer protein inhibitors. N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)- trifluoro-3-amino-2-propanol derivatives has screened as antiatherogenic agents. So, N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3- phenoxyphenyl)trifluoro-3-amino-2-propanol derivatives were selected for quantitative structure activity relationships, for the present study. QSAR studies with significant equations indicate that the molar refractivity in the R₃ position of the parent compound negatively contributed for activity.