Hydrotropic Solubilization in Spectrophotometric Analysis of Cefixime in Solid Dosage Form

Abstract

Various techniques are employed to enhance the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilization is one of them. In the present investigation, cefixime has been selected as a poorly water-soluble model drug. There were more than 120 and 240 fold enhancements in aqueous solubility of cefixime by 8 M potassium acetate and 6 M ammonium acetate solutions, respectively as compared to aqueous solubility. These hydrotropic agents were employed to solubilize the drug from the fine powder of tablet formulations. The selected λ_max for spectrophotometric estimation was 288 nm. The hydrotropic agents and the additives used in the manufacturing of tablets did not interfere in the analysis.