Synthesis and Biological Activity of Phenyl Amino Acetic Acid (2-Oxo-1,2-dihydroindol-3-ylidene)hydrazides

Abstract

In present work, some new phenyl amino acetic acid (2-oxo-1,2-dihydroindol-3-ylidene)hydrazides (4) were prepared. Aniline was refluxed with ethyl cholroacetate in dry acetone in presence of anhydrous potassium carbonate to prepare ethylphenylaminoacetate (1) which on subsequent reaction with hydrazine hydrate to yield phenyl amino acetic acid hydrazide (2). This compound was refluxed with different isatins (3) to get the phenyl amino acetic acid (2-oxo-1,2- dihydroindol-3-ylidene)hydrazides (4). The structures of the products were characterized by spectral studies (IR, PMR and mass). All the compounds were evaluated for antibacterial and antifungal activities.