Microwave Promoted Suzuki Cross-coupling Reactions of Quinazoline Halides with Aryl boronic Acids

Abstract

The microwave promoted Suzuki coupling reaction of quinazoline halides with boronic acids performed was studied using stable catalyst tetrakis triphenyl phosphine palladium (0). This catalyst under microwave conditions (175ºC, 6 m) provided coupled products with yields ranging from 76 to 90%. This method tolerated a variety of boronic acids in the absence of ligand.