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"Side-Off"-Schiff Base Copper Complexes: Synthesis, Characterization and Cytotoxic Activity in A549 Cell Line
Corresponding Author(s) : S.H. Anjana Lakshmi
Asian Journal of Chemistry,
Vol. 30 No. 12 (2018): Vol 30 Issue 12
Abstract
A unique series of binuclear "Side-off" Schiff base copper complexes, viz. complex A, B and C were synthesized and characterized by the optical physical probes and further, in vitro cytotoxic activity of the complexes was evaluated on A549 lung carcinoma cell line. The metal complexes were dissolved in DMSO at various concentrations (1000, 500, 250, 100, 50, 25, 10, 5 and 2.5 μM) of each compound were prepared for exposure to A549 cell line. MTT-Cell viability assay was performed to assess the cytotoxicity of the compounds. Out of three copper complexes synthesized in this study, compound C exhibited notable cytotoxic effects in human lung (A549) cancer cell lines after 24 h treatment. Further investigations on the precise mechanism of action are underway to achieve a better understanding over the cytotoxicity mechanism.
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M. Plotek, K. Dudek and A. Kyziolmarzano, Chemik, 67, 1181 (2013).
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T. Storr, K.H. Thompson and C. Orvig, Chem. Soc. Rev., 35, 534 (2006); https://doi.org/10.1039/b514859f.
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T. Mosmann, J. Immunol. Methods, 65, 55 (1983); https://doi.org/10.1016/0022-1759(83)90303-4.
B.S. Creaven, B. Duff, D.A. Egan, K. Kavanagh, G. Rosair, V.R. Thangella and M. Walsh, Inorg. Chim. Acta, 363, 4048 (2010); https://doi.org/10.1016/j.ica.2010.08.009.
D. Senthil Raja, N.S.P. Bhuvanesh and K. Natarajan, J. Biol. Inorg. Chem., 17, 223 (2012); https://doi.org/10.1007/s00775-011-0844-1.
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