Synthesis of {Substituted-[(4-{[4-(carboxymethylcarbamoyl) phenylimino]methyl}benzylidene)-amino]benzoylamino}carboxylic Acids

Abstract

Some novel derivatives of methotrexate like compounds 2a-f have been synthesized, using terephthalaldehyde, isophthalaldehyde, 4-aminobenzoic acid and amino acids (glycine, β-alanine, L-glutamic acid). The structures of the products were identified by spectroscopic methods and antimicrobial effects of these compounds have been investigated on bacterial and yeast cells.