Synthesis and Evaluation of Antioxidant Activity of 6-Methoxy-2H-chromenes

Abstract

3-(6-Methoxy-2H-chromen-3-yl)-1-phenyl prop-2-en-1-one and 1-(6-methoxy-2H-chromen-3-yl)-3-phenyl prop-2-en-1-one were synthesized by condensation of 6-methoxy-2H-chromen-3-carbaldehyde or 1-(6-methoxy-2H-chromen-3-yl)ethanone with acetophenone or benzaldehyde, respectively. The synthesized chalcones were evaluated for their antioxidant activity using ferric reducing antioxidant power (FRAP) and DPPH free radical scavenging methods. Both compounds showed antioxidant activity, in comparison with trolox.