One-Pot Synthesis under Ultrasonic Irradiation of N-(Substituted phenyl)-N´-(5-methylisoxazoyl)-Thiourea Derivatives

Abstract

Reaction of substituted aniline with 5-methylisoxazoyl chloride and ammonium thiocyanate under the condition of solid-liquid phase-transfer catalysis using polyethylene glycol- 600 (PEG-600) as the catalyst under ultrasonic irradiation yielded N-(substituted phenyl)-N'-(5-methylisoxazoyl)- thiourea derivatives 3a-3j in good-to-excellent yield. The chemical structure of all compounds was established by ¹H NMR, FTIR, MS and elemental analysis studies.