Two UV-Spectrophotometric Methods for Simultaneous Determination of Levofloxacin and Ambroxol in Tablets

Abstract

Two simple, rapid, accurate and precise UV-spectrophotometric methods have been developed for simultaneous estimation of levofloxacin and ambroxol from tablets. Method 1 involves formation and solving of simultaneous equations, while method 2 multicomponent mode of analysis. In distilled water, the absorbance maxima for levofloxacin and ambroxol was found to be 226 and 244 nm, respectively. The linearity was observed in the concentration range of 4-20 μg/ mL for levofloxacin and 4-40 μg/mL for ambroxol. The results of both the methods have been validated statistically and by recovery studies.