Antiinflammatory and Antinociceptive Properties of Luteolin Diglucuronide and Apigenin Diglucuronide Obtained from Perilla nankinensis

Abstract

This study aimed to examine possible antiinflammatory and antinociceptive effects of luteolin diglucuronide (LT), apigenin diglucuronide (AP) and semi-pure luteolin diglucuronide (S-LT) obtained from Perilla nankinensis in rats and mice. Antiinflammatory effects of LT, AP and S-LT were investigated with the carrageenaan-induced rat paw edema tests. It was found that pretreatment with LT, AP and S-LT obtained from Perilla nankinensis reduced inflammagen -induced paw edema in rats. Again, pretreatment with LT significantly diminished the nociceptive response in mice. LT and AP present in the leaves of Perilla nankinensis may partly account for the antiinflammatory and antinociceptive properties of Perilla nankinensis.