Synthesis and Antiinflammatory Activity of Some New Indolyl Substituted Quinazolin-4-(3H)-ones

Abstract

A series of 2-methyl-3-(2'-substituted indol-3'-yl)-substituted quinazolin-4(3H)-ones (1-2), 2-chloroacetylmethylene- 3-(2'-substituted indol-3'-yl)-substituted quinazolin-4(3H)- ones (3-4), 2-hydrazinoacetylmethylene-3-(2'-substitutedindol- 3'-yl)-substituted quinazolin-4(3H)-ones (5-6), 2-(substituted phenylmethyleneimino)aminoacetylmethylene- 3-(2'-substituted indol-3'-yl)-substituted quinazolin-4(3H)- ones (7-14) and 2-(substituted phenylaminomethyleneacetyl- 4'-oxo-3'-thiazalidinyl)-3-(2"-substituted indol-3"-yl)-substituted quinazolin-4(3H)-ones (15-22) have been synthesized. The compounds were screened for their antiinflammatory activity and were compared with the standard drug phenylbutazone. Out of these compounds the most active was 2-(p-chlorophenyl aminomethylacetyl-4'-oxo-1'-thiazolidinyl)-3- (indol-3"-yl)-6,8-dibromo quinazokin-4(3H)-one (19). The structures of these compounds have been confirmed by elemental and spectral analysis.