Spectrophotometric Determination of Rosiglitazone Maleate in Tablets

Abstract

Two new, simple and sensitive spectrophotometric methods in ultraviolet and visible region, respectively have been developed for the determination of rosiglitazone maleate in bulk and in tablets. In method I rosiglitazone showed absorption maxima at 248.5 nm in methanol and obeyed beer’s law in the concentration range of 2-20 μg/mL. In method II rosiglitazone maleate reacted with diazotized sulphanillic acid in an alkaline medium to form yellowish orange chromogen. Chromogen obeyed Beer's law in the concentration range of 10-60 μg/mL at λ_max of 475.7 nm. Statistical analysis and recovery studies validated the methods.