Synthesis and Characterization of Carboxamides of 2´-Amino-4´-[3-(2H-1-benzopyran-2-one)]thiazole as Antimicrobial Agents

Abstract

A series of carboxamides of aminothiazolyl 2H-1-benzopyran- 2-one were synthesized by treating 2'-amino-4'-[3-(2H- 1-benzopyran-2-one)]thiazole with acid chlorides. The former compound was obtained by cyclizing 3-bromoacetyl 2H-1- benzopyran-2-one with thiourea. The structure of the synthesized compounds have been characterized on the basis of spectral data such as IR, ¹H NMR and mass spectral studies and evaluated for antibacterial activity by agar cup plate method. Out of the compounds tested, few showed significant antibacterial activity.