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Vol. 20 No. 6 (2008): Vol 20 Issue 6

Thermal Degradation Study in the Process Development of Atorvastatin Calcium¶

K. Srinivas
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
A. Kalyan Chakravarthy
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
K. Rajasekhar
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
G. Srinivasulu
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
K.J. Sathyanarayana
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
P.K. Dubey
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India
P. Pratap Reddy
Dr. Reddy's Laboratories Limited, Integrated Product Development, Innovation Plaza Survey Nos. 42, 45, 46 and 54 Bachupally, Qutubullapur, Hyderabad-500 072, India

Corresponding Author(s) : P. Pratap Reddy

pratapp@drreddys.com

Asian Journal of Chemistry, Vol. 20 No. 6 (2008): Vol 20 Issue 6

Abstract

As a part of process development, thermal degradation pathway of atorvastatin calcium, an HMG-COA reductase, is studied. All the five compounds obtained in this process are fully characterized.

Keywords

Thermal degradation Atorvastatin calcium
(1)
Srinivas, K.; Kalyan Chakravarthy, A.; Rajasekhar, K.; Srinivasulu, G.; Sathyanarayana, K.; Dubey, P.; Pratap Reddy, P. Thermal Degradation Study in the Process Development of Atorvastatin Calcium¶. ajc 2010, 20, 4813-4816.
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