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Quantitative Determination of Dexamethasone in Pharmaceutical Tablets with Continuous Wavelet Transforms
Corresponding Author(s) : E. Buker
Asian Journal of Chemistry,
Vol. 30 No. 11 (2018): Vol 30 Issue 11
Abstract
The UV absorption spectra were processed by using the continuous wavelet transform for the determination of dexamethasone in tablets. In order to get optimal wavelet transform, some wavelet families were tested to transform the UV-absorption spectra of the related drug in the spectral region of 210.0-312.3 nm. In the test procedure of wavelet families, it was observed that Mexican hat function-continuous wavelet transform (mexh-CWT) and Daubechies 8-continuous wavelet transform (db8-CWT) were appropriate for the UV spectra for the quantitative estimation of dexamethasone. The validity of proposed continuous wavelet transform signal analysis methods were performed by using the analysis results of the solutions for validation samples. In the method validation studies, the percent recoveries and their relative standard deviations were found as 100.7 % and 0.78 for mexh-CWT procedure and 100.2 % and 1.28 for db8-CWT procedure. It was concluded that both mexh-CWT and db8-CWT methods were useful approaches for the determination of dexamethasone in tablets.
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- World Health Organization, WHO Model List of Essential Medicines, World Health Organization (2013).
- M. Chen, X. Zhang, Q. Shao and L. Gan, Yaowu Fenxi Zazhi, 11, 103 (1991).
- M. Xi, Y. Yang, Q. Shao and Y. Peng, Yaowu Fenxi Zazhi, 11, 291 (1991).
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- K. Datta and S.K. Das, J. Planar Chromatogr Mod. TLC, 6, 204 (1993).
- B. Das, S.K. Chatterjee and S.K. Das, J. Liq. Chromatogr., 9, 3461 (1986); https://doi.org/10.1080/01483918608077796.
- I. Daubechies, Ten Lectures on Wavelets, Society for Industrial and Applied Mathematics, Philadelphia, PA, USA (1992).
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- E. Dinç and D. Baleanu, eds.: K. Tas, J.A. Tenreiro Machado and D. Balanu, Mathematical Methods in Engineering, Springer, pp. 265-285 (2007).
References
World Health Organization, WHO Model List of Essential Medicines, World Health Organization (2013).
M. Chen, X. Zhang, Q. Shao and L. Gan, Yaowu Fenxi Zazhi, 11, 103 (1991).
M. Xi, Y. Yang, Q. Shao and Y. Peng, Yaowu Fenxi Zazhi, 11, 291 (1991).
X. Yao and Z. Qiao, Yiao. Gongye, 19, 172 (1988).
D. Gagne and B.A. Lodge, J. Chromatogr. A, 193, 160 (1980); https://doi.org/10.1016/S0021-9673(00)81459-4.
V.D. Gupta, J. Pharm. Sci., 68, 926 (1979); https://doi.org/10.1002/jps.2600680743.
K. Datta and S.K. Das, J. Planar Chromatogr Mod. TLC, 6, 204 (1993).
B. Das, S.K. Chatterjee and S.K. Das, J. Liq. Chromatogr., 9, 3461 (1986); https://doi.org/10.1080/01483918608077796.
I. Daubechies, Ten Lectures on Wavelets, Society for Industrial and Applied Mathematics, Philadelphia, PA, USA (1992).
B. Walczak, Wavelets in Chemistry, Elsevier Press: Amsterdam, The Netherlands. vol. 22, pp. 241-261 (2000).
E. Dinç and D. Baleanu, eds.: K. Tas, J.A. Tenreiro Machado and D. Balanu, Mathematical Methods in Engineering, Springer, pp. 265-285 (2007).