Selective Protection of Alcohols as 2-Tetrahydropyranyl Acetals Using Keggin H3PW12O40 Effect of Different Reaction Parameters

Abstract

Selective protection of some industrially and pharmaceutically important chemicals bearing primary and secondary hydroxyl groups were achieved using 3,4-dihydro-2H-pyran (DHP) as the protecting group by the presence of Keggin H₃PW₁₂O₄₀ as catalyst. Findings revealed only protection of the primary alcoholic group in good yields. Different reaction parameters affecting efficiency of the formation of 2-tetrahydropyranyl acetals from alcohols catalyzed by H₃PW₁₂O₄₀ were also studied. Characteristic reaction conditions include short times and room temperature.