Issue

Vol. 30 No. 11 (2018): Vol 30 Issue 11

Copyright (c) 2018 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Optimization of Extraction Process and Simultaneous Determination of Flurbiprofen and Methyl Salicylate in Marketed Topical Gel Formulation by Vierodt’s Method

https://doi.org/10.14233/ajchem.2018.21458
Shivani Sawant
Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji-403 001, India
Karishma Naik
Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji-403 001, India
P.N. Sanjay Pai
Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji-403 001, India

Corresponding Author(s) : P.N. Sanjay Pai

pnsanjaypai@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 11 (2018): Vol 30 Issue 11

Abstract

Flurbiprofen (FLB) and methyl salicylate (MS), the actives in a commercial topical gel formulation were extracted for their simultaneous estimation. The extraction system was optimized, validated for elimination of interferences associated with matrix materials used in the formulation and also compensate for possible interference of one drug by the other during analysis. An efficient extraction procedure was developed for the separation of flurbiprofen and methyl salicylate from the marketed formulation Brugel and analyzed for the content with a new validated vierodt’s simultaneous equation method. Detection wavelengths of 248 and 304 nm were used for recording the absorbance as they represent the absorption maxima of flurbiprofen and methyl salicylate respectively. Simultaneous equations were designed to estimate the unknown concentration of both the components in the marketed formulation. Linearity was calculated using standard stock solution of methyl salicylate and flurbiprofen in the concentration range of 5-30 μg/mL. The developed method was found to be specific, precise, accurate and can be used for routine analysis of flurbiprofen and methyl salicylate in marketed gel formulations.

Keywords

Flurbiprofen Methyl salicylate Gel Extraction Simultaneous equation
Sawant, S., Naik, K., & Pai, P. S. (2018). Optimization of Extraction Process and Simultaneous Determination of Flurbiprofen and Methyl Salicylate in Marketed Topical Gel Formulation by Vierodt’s Method. Asian Journal of Chemistry, 30(11), 2477–2480. https://doi.org/10.14233/ajchem.2018.21458
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. R.A. Moore, S. Derry and H.J. McQuay, Rheum. Dis. Clin. North Am., 34, 415 (2008); https://doi.org/10.1016/j.rdc.2008.03.006.
  2. C.M. Lee and H.I. Maibach, J. Pharm. Sci., 95, 1405 (2006); https://doi.org/10.1002/jps.20666.
  3. Y. Chen, P. Quan, X. Liu, W. Guo, W. Song, D. Cun, Z. Wang and L. Fang, J. Pharm. Pharmacol., 67, 1232 (2015); https://doi.org/10.1111/jphp.12428.
  4. S.E. Cross C. Anderson and M.S. Roberts, Br. J. Clin. Pharmacol., 46, 29 (1998); https://doi.org/10.1046/j.1365-2125.1998.00045.x.
  5. V. Adepu, K.E.V. Nagoji and V.G. Sastry, Indo Am. J. Pharm. Res., 6, 6736 (2016).
  6. M. Hanif, N. Nazer, V. Chaurasiya and U. Zia, Trop. J. Pharm. Res., 15, 605 (2016); https://doi.org/10.4314/tjpr.v15i3.24.
  7. S. Naveed, F. Zafar, H. Ali, H. Dilshad, F. Qamar, S.S. Abbas, N. Waheed, S. Nazeer and Z. Ashraf, Lat. Am. J. Pharm., 34, 1432 (2015).
  8. R. Sandip and A.K. Joshi, Int. J. Universal Pharm. Bio. Sci., 3, 1 (2014).
  9. B. Rajani and K. Mukkanti, Int. J. Pharm., 4, 309 (2014).
  10. G. Patel, P. Chauhan and S. Shah, Am. J. Pharmtech. Res., 4, 658 (2014).
  11. I.U. Khan, S.N. Razzaq, I. Mariam, M. Ashfaq and S.S. Razzaq, Quim. Nova, 37, 349 (2014); https://doi.org/10.5935/0100-4042.20140058.
  12. V. Kokane, S. Bhosale and S. Naik, Int. J. Pharm. Res. Bio-Sci., 4, 341 (2015).
  13. M. Tariq, Z. Iqbal, J. Ali, S. Baboota, R. Parveen, M. Mirza, S. Ahmad and J. Sahni, J. Planar Chromatogr., 27, 124 (2014); https://doi.org/10.1556/JPC.27.2014.2.10.
  14. B. Yilmaz and E. Alkan, Arab. J. Chem.; https://doi.org/10.1016/j.arabjc.2014.12.038.
  15. J.P. Sapio, K. Sethachutkul and J.E. Moody, J. Pharm. Sci., 68, 506 (1979); https://doi.org/10.1002/jps.2600680431.
  16. V. Adepu and K.E.V. Nagoji, Int. J. Pharm. Pharm. Sci., 6, 31 (2014).
  17. P.K. Pradhan, P.N. Rajput, N. Kumar, B. Joshi and U.M. Upadhyay, Int. J. Pharm. Sci. Rev. Res., 27, 96 (2014).
  18. G. Patel, P. Chauhan and S. Shah, J. Chem. Pharm. Res., 6, 96 (2014).
  19. R.N. Saha, S. Chandran, P.R. Jadhav and P.B. Kharwade, Indian J. Pharm. Sci., 68, 20 (2006); https://doi.org/10.4103/0250-474X.22958.
  20. S. Mazurek and R. Szostak, Vib. Spectrosc., 83, 1 (2016); https://doi.org/10.1016/j.vibspec.2015.12.005.
  21. D. Dorwal, Int. J. Res. Pharm. Biomed. Sci., 3, 98386 (2012).
  22. L. Nováková, D. Solichová and P. Solich, J. Sep. Sci., 29, 2433 (2006); https://doi.org/10.1002/jssc.200600147.
  23. R. Dubey, M. Bommagani, V. Venkateswarlu, R. Mullangi, H.R. Karnati, R.K. Thammera and V.C.A. Menon, J. Pain Palliat. Care Pharmacother., 23, 26 (2009); https://doi.org/10.1080/15360280902728062.
  24. C. Roy, J. Chakrabarty and P.B. Modi, Indian J. Pharm. Sci., 75, 197 (2013); https://doi.org/10.4103/0250-474X.115468.
  25. L. Nováková, L. Matysová, L. Havlíková and P. Solich, J. Pharm. Biomed. Anal., 37, 899 (2005); https://doi.org/10.1016/j.jpba.2004.09.012.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0