An Efficient Process for The Synthesis of Anti-Obesity Drug Rimonabant
Corresponding Author(s) : M.V. Surayanarayana
kalyanch@drreddys.com
Asian Journal of Chemistry,
Vol. 21 No. 2 (2009): Vol 21 Issue 2
Abstract
A convenient and cost effective synthetic process has been developed for the synthesis of an anti-obesity drug rimonabant (1). The process involves the condensation of 4-chloro propiophenone with diethyl oxalate to get the diketo ester (3), which upon reaction with N-amino piperidine followed by acid catalyzed cyclization with 2,4-dichloro phenyl hydrazine hydrochloride afforded rimonabant (1) in good overall yield.
Keywords
Rimonabant
Anti-obesity drug
Diketo ester
Seetharama Sarma, P., Surayanarayana, M., Nageswar Rao, C., Pratap Reddy, P., Khalilulah, M., Praveen, C., & Kalyan Chakravarthy, A. (2010). An Efficient Process for The Synthesis of Anti-Obesity Drug Rimonabant. Asian Journal of Chemistry, 21(2), 1171–1175. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18805
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