Synthesis and Antimicrobial Activity of Some Thiazolidinone Derivatives from 2-Methyl, 8-hydroxy Quinoline

Abstract

A series of thiazolidinone derivatives were synthesized from 2-methyl, 8-hydroxy quinoline. Schiff bases were prepared by condensation of hydrazide of quinoline moiety with different aromatic aldehydes (3a-3i). Cyclocondensation of Schiff bases with thioglycollic acid in presence of anhydrous zinc chloride yielded a series of thiazolidinones (4a-4i). The structures of the synthesized compounds have been established by IR, ¹H NMR and mass spectra.The compounds have been screened for their antibacterial and antifungal activities.