Simultaneous Estimation of Residual Solvents (Isopropyl Alcohol and Dichloromethane) in Dosage Form by GC-HS-FID
Corresponding Author(s) : Praveen Kumar Baliyan
praveenbaliyanraj@yahoo.co.in
Asian Journal of Chemistry,
Vol. 21 No. 3 (2009): Vol 21 Issue 3
Abstract
A simple and sensitive method for the determination of isopropyl alcohol and dichloromethane as residual solvent was developed and validated on gas liquid chromatography with headspace sampler fitted with flame ionization detector (GC-HS-FID). The carrier gas was helium and separation was carried out on Elite-624 (30 meter, 0.53 mm ID, 3μm df) capillary column consisting of 6 % cyanopropylphenyl - 94 % dimethyl polysiloxane stationary phase. The retention time for isopropyl alcohol and dichloromethane were 10.8, 11.4 min, respectively.
Keywords
Isopropyl alcohol
Dichloromethane
GC-HS-FID
Kumar Baliyan, P., Singh, R., & Arora, S. (2010). Simultaneous Estimation of Residual Solvents (Isopropyl Alcohol and Dichloromethane) in Dosage Form by GC-HS-FID. Asian Journal of Chemistry, 21(3), 1739–1746. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18652
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX