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Vol. 26 No. 18 (2014): Vol 26 Issue 18

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Preparation and Properties Evaluation of Chitosan/Alginate Hydrogels in Drug Controlled Release

https://doi.org/10.14233/ajchem.2014.17467
X.F. Zheng
College of Chemistry and Chemical Engineering, Hebei Normal University of Science and Technology, Qinhuangdao 066600, P.R. China
Q. Lian
College of Chemistry and Chemical Engineering, Hebei Normal University of Science and Technology, Qinhuangdao 066600, P.R. China

Corresponding Author(s) : Q. Lian

xuefang-zheng@163.com

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18

Abstract

pH-sensitive hydrogels based on chitosan-sodium alginate was synthesized by using glutaradehyde as cross-link agent. The effects of the degree of the dosage of crosslinking and pH on the swelling behaviours of the hydrogel have been studied and the swelling ratio of this hydrogel in acide solution is much larger than that in alkaline solution. The release behaviour of bovine serum albumin entrapped in the hydrogels was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum albumin in those two kinds of hydrogels in the medium of pH=1 was much quicker in pH=7.4 and 9.18. The amount of bovine serum albumin released from the films at different time intervals was estimated by UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that chitosan-sodium alginate hydrogels were promising for controlled delivery of the drug. Formulation containing chitosan and sodium alginate may be suitable as a coating formulation for colon targeted drug delivery.

Keywords

Chitosan Sodium alginate Bovine serum albumin Controlled release
Zheng, X., & Lian, Q. (2014). Preparation and Properties Evaluation of Chitosan/Alginate Hydrogels in Drug Controlled Release. Asian Journal of Chemistry, 26(18), 6257–6260. https://doi.org/10.14233/ajchem.2014.17467
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References
  1. R.A.A. Muzzarelli, Carbohydr. Polym., 29, 309 (1996); doi:10.1016/S0144-8617(96)00033-1.
  2. R.A.A. Muzzarelli, Natural Chelating Polymers, Pergamon Press Ltd, Oxford (1973).
  3. H.I. Bolker, Natural and Synthetic Polymer: An Introduction, Marcel Dekker Inc., New York (1974).
  4. J.D. Dee, O. Rhode and R. Wachter, Cosmetics and Toiletries, 116, 39 (2001).
  5. A.K. Singla and M.J. Chawla, Pharm. Pharmacol., 53, 1047 (2001); doi:10.1211/0022357011776441.
  6. H.K. No and S.P.J. Meyers, Agric. Food Chem., 37, 580 (1989); doi:10.1021/jf00087a002.
  7. K. Kurita, Polym. Degrad. Stab., 59, 117 (1998); doi:10.1016/S0141-3910(97)00160-2.
  8. S.E. Bailey, T.J. Olin, R.M. Bricka and D.D. Adrian, Water Res., 33, 2469 (1999); doi:10.1016/S0043-1354(98)00475-8.
  9. Y. Sawayanagi, N. Nambu and T. Nagai, Chem. Pharm. Bull. (Tokyo), 31, 2064 (1983); doi:10.1248/cpb.31.2064.
  10. T.C. Yang and R.R. Zall, Ind. Eng. Chem. Prod. Res. Dev., 23, 168 (1984); doi:10.1021/i300013a033.
  11. J.-K. Yang, I.-L. Shih, Y.-M. Tzeng and S.-L. Wang, Enzyme Microb. Technol., 26, 406 (2000); doi:10.1016/S0141-0229(99)00164-7.
  12. T.A. Khan, K.K. Peh and H.S.J. Ch’ng, Pharm. Sci., 5, 205 (2002).
  13. T.D. Jiang, Chitosan, Huaxue Gongye Chubanshe, Beijing, pp. 256-258 (2001).
  14. X.B. Li and H. Zhu, Yaoxue Jinzhan, 29, 166 (2005).
  15. S.M. Ding, X.H. Feng, Y.T. Wang and Q. Peng, Fenxi Kexue Xuebao, 21, 127 (2005).
  16. O. Pillai and R. Panchagnula, Curr. Opin. Chem. Biol., 5, 447 (2001); doi:10.1016/S1367-5931(00)00227-1.
  17. E. Khor and L.Y. Lim, Biomater., 24, 2339 (2003); doi:10.1016/S0142-9612(03)00026-7.
  18. S. Xin-Yuan, Bioact. Compat. Polym., 19, 467 (2004); doi:10.1177/0883911504048410.
  19. G. Crini, Bioresour. Technol., 97, 1061 (2006); doi:10.1016/j.biortech.2005.05.001.
  20. M. Kerec, M. Bogataj, P. Veranic and A. Mrhar, Eur. J. Pharm. Sci., 25, 113 (2005); doi:10.1016/j.ejps.2005.02.003.
  21. L.Y. Chen, Z.G. Tian and Y.M. Du, Biomaterials, 25, 3725 (2004); doi:10.1016/j.biomaterials.2003.09.100.
  22. Y.H. Lin, H.F. Liang, C.K. Chung, M.-C. Chen and H.-W. Sung, Biomaterials, 26, 2105 (2005); doi:10.1016/j.biomaterials.2004.06.011.
  23. N.A. Peppas, Pharm. Acta Helv., 60, 110 (1985).
  24. L.B. Peppas, Med. Plast. Biomater., 4, 34 (1997).
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