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Vol. 26 No. 18 (2014): Vol 26 Issue 18

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Synthesis, Antibacterial Activity and Antifouling Property of Novel Indole Compounds Containing Acylamino Groups

https://doi.org/10.14233/ajchem.2014.17415
Xia Li
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P.R. China
Chun-Hua Ni
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P.R. China
Liang-Min Yu
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P.R. China
Jing Zhao
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P.R. China
Xue-Feng Yan
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P.R. China

Corresponding Author(s) : Xue-Feng Yan

yanxuefeng@ouc.edu.cn

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18

Abstract

Due to the environmentally harmful impact of tributyltin self-polishing paints and other "tributyltin-free" chemically active paints, there is a critical need of more ecological alternatives. In this work, 9 novel N-substituted indoles each bearing a acylamino group were synthesized and the structures of 2a-2i were established by 1H NMR, IR spectra and elemental analysis. The antibacterial activity of the synthesized compounds against Escherichia coli and Staphylococcus aureus as well as antifouling activity were studied. The results showed that these compounds possessed a broad spectrum of activity having MIC values of 0.01-0.5 mg/mL against the tested bacteria and antifouling property was superior to cuprous oxide which is widely used as antifoulants. This provided theoretical and technical support for the preparation of environmental friendly antifouling coatings.

Keywords

Indole Acylamino groups Synthesis Antibacterial activity Antifouling property
Li, X., Ni, C.-H., Yu, L.-M., Zhao, J., & Yan, X.-F. (2014). Synthesis, Antibacterial Activity and Antifouling Property of Novel Indole Compounds Containing Acylamino Groups. Asian Journal of Chemistry, 26(18), 6253–6256. https://doi.org/10.14233/ajchem.2014.17415
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