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Vol. 26 No. 18 (2014): Vol 26 Issue 18

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Cholinesterase Inhibitory Triterpenes from Perovskia atriplicifolia

https://doi.org/10.14233/ajchem.2014.17001
S. Perveen
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia
A.M. AL-Taweel
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia
G.A. Fawzy
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
T.A. Ibrahim
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
A. Malik
International Centre for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
A. Khan
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

Corresponding Author(s) : G.A. Fawzy

gzeineldin@outlook.com; gfewzy@ksu.edu.sa

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18

Abstract

Nine compounds including b-amyrin (1), erythrodiol (2), oleanolic acid (3), 3b-hydroxy-11,13(18)-oleanadien-28-oic acid (4), glycyrrhetinic acid (5), 2a,3b-dihydroxyolean-12-en-28-methyl ester (6), 2a,3b-dihydroxyolean-12-en-28-oic acid (7), 2a,3b,24-trihydroxyolean-12-en-28-oic acid (8) and 2a,3b,19b-trihydroxyurs-12-en-28-oic acid (9), have been isolated from Perovskia atriplicifolia. Their structures have been established with the help of different spectral data. All of these compounds were tested for cholinesterase inhibitory activity. Among the tested compounds, 8 and 9 were found to be the most active against both enzymes, with a significant butyrylcholinesterase (BChE) inhibitory activity demonstrating IC50 values 9.50 and 13.52 mM, respectively, compared to galanthamine standard (IC50: 8.51 mM).

Keywords

Cholinesterase inhibition Lamiaceae Perovskia atriplicifolia Triterpenes
Perveen, S., AL-Taweel, A., Fawzy, G., Ibrahim, T., Malik, A., & Khan, A. (2014). Cholinesterase Inhibitory Triterpenes from Perovskia atriplicifolia. Asian Journal of Chemistry, 26(18), 6163–6166. https://doi.org/10.14233/ajchem.2014.17001
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