Synthesis, Characterization and Antimicrobial Potential of Novel Conjugated Schiff Bases

Ameer Fawad Zahoor; Muhammad Yousaf; Asim Mansha; Shazia Naheed; Matloob Ahmad; Anbreen Anjum; Kiran Aftab; Abdul Ghaffar; Sajjad Ahmad; Ali Irfan

doi:10.14233/ajchem.2014.16992

Issue

Vol. 26 No. 18 (2014): Vol 26 Issue 18

Issue Published : September 1, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Antimicrobial Potential of Novel Conjugated Schiff Bases

https://doi.org/10.14233/ajchem.2014.16992

Ameer Fawad Zahoor

Department of Chemistry, Government College University, Faisalabad, Pakistan

Muhammad Yousaf

Department of Chemistry, Government College University, Faisalabad, Pakistan

Asim Mansha

Department of Chemistry, Government College University, Faisalabad, Pakistan

Shazia Naheed

Department of Chemistry, Government College University, Faisalabad, Pakistan

Matloob Ahmad

Department of Chemistry, Government College University, Faisalabad, Pakistan

Anbreen Anjum

Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan

Kiran Aftab

Department of Chemistry, Government College University, Faisalabad, Pakistan

Abdul Ghaffar

Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, Pakistan

Sajjad Ahmad

University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, Pakistan

Ali Irfan

Department of Chemistry, Government College University, Faisalabad, Pakistan

Corresponding Author(s) : Muhammad Yousaf

dryousafsmor@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18
Article Published : September 2, 2014

Abstract

Anthracenylamine and naphthylamine were reacted with 1, 3-cyclohexadienone and 1, 4- benzoquinone in order to prepare four (1, 2, 3 & 4) conjugated Schiff bases for the evaluation of their antibacterial as well as antifungal activities. The results of their activities were compared with standard drugs against three strains of bacteria as well as three strains of fungi and they showed that the Schiff base 4 (C₃₄H₂₂N₂O) exhibited good inhibition zones against all the strains of bacteria (10.74 ± 0.65, 10 ± 0.675, 10.65 ± 0.75 mm) as well as fungi (9.15 ± 0.815, 10.25 ± 0.55, 10.5 ± 0.575 mm) as compared to others (1, 2 & 3). The Schiff base 3 (C₂₆H₂₄N₄) showed better potential for S. aureus (10 ± 0.856 mm) strain of bacteria and A. alternate (10.5 ± 2.150 mm) strain of fungi. Its activity against other two strains of bacteria and fungi was also better than other two Schiff bases (1 & 2). The Schiff base 2 (C₂₆H₂₂N₂) exhibited reasonable activity against B. subtilus (10 ± 0.715 mm) and A. alternate (8.55 ± 0.015 mm). The compound (1) showed least antibacterial (4.5 ± 0.815, 5 ± 0.716, 4.75 ± 0.950 mm) as well as antifungal (4 ± 0.575, 4.15 ± 0.570, 6.5 ± 1.725 mm) activity. From the results it is concluded that delocalization of p electrons has the positive influence on the antimicrobial potential of the titled Schiff bases. Thus these Schiff bases may serve as a basis for the chemical modifications directed towards the development of a new class of antibacterial agents.

Keywords

Conjugated Schiff base Bacterial strains Fungal strains Activity

Fawad Zahoor, A., Yousaf, M., Mansha, A., Naheed, S., Ahmad, M., Anjum, A., … Irfan, A. (2014). Synthesis, Characterization and Antimicrobial Potential of Novel Conjugated Schiff Bases. Asian Journal of Chemistry, 26(18), 6159–6162. https://doi.org/10.14233/ajchem.2014.16992

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References

T.D. Chaudhari and S.S. Subnis, Bull. Haffkine, 4, 85 (1986).

S. Shah, R. Vyas and R.H. Mehta, J. Indian Chem. Soc., 69, 590 (1992).

K. Sahu, R.K. Behera, R.C. Pathaik, A. Nayak and G.B. Behera, Indian J. Chem., 18B, 557 (1979).

M. Abdul-Gawad, Y.M. Issa and S.M. Abd-Alhamid, Egypt. J. Pharm. Sci., 34, 219 (1993).

S.A. Khan, A.A. Siddiqui and S. Bhatt, Asian J. Chem., 14, 117 (2002).

A. Elmali, M. Kabak and Y. Elerman, J. Mol. Struct., 477, 151 (2000).

S.N. Pandeya, D. Sriram, G. Nath and E. Declercq, Eur. J. Pharm., 9, 25 (1999); doi:10.1016/S0928-0987(99)00038-X.

R. Mladenova, M. Ignatova, N. Manolova, T. Petrova and I. Rashkov, Eur. Polym. J., 38, 989 (2002); doi:10.1016/S0014-3057(01)00260-9.

P. Singh, R.L. Goel and B.P. Singh, J. Indian Chem. Soc., 52, 958 (1975).

D. Singh, K. Kumar, S.S. Dhiman and J. Sharma, J. Enzyme Inhib. Med. Chem., 25, 21 (2010); doi:10.3109/14756360902932750.

A.D. Logu, V. Onnis, B. Saddi, C. Congiu, M.L. Schivo and M.C. Cocco, J. Antimicrob. Chemother., 49, 275 (2002); doi:10.1093/jac/49.2.275.

M. Cuenca-Estrella, B. Ruiz-Diez, J.V. Martinez-Suarez, A. Monzon and J.L. Rodriguez-Tudela, J. Antimicrob. Chemother., 43, 149 (1999); doi:10.1093/jac/43.1.149.

M. Akbar, F. Naser and K. Mehdi, Turk. J. Chem., 34, 367 (2010).

A.A. Al-meiry, Y.K. Al-majedy, H.A. Ibrahim and A.A. Al-tamimi, Org. Med. J., 2, 4 (2012).

M.R. Karekal, V. Biradar and M. Bennikallu Hire Mathada, Bioinorg. Chem. Appl., Article ID 315972, (2013); doi:10.1155/2013/315972.

X. Xiao, W. Jiag-Thao and B. Jie, J. Chem. Eng .Chinese Univ., 4, 160 (2010).

J. Sunny, J. Anil, G. Avneet and Hemraj, Asian J. Pharm. Clin. Res., 5,199,(2012).

Issue

Vol. 26 No. 18 (2014): Vol 26 Issue 18

Synthesis, Characterization and Antimicrobial Potential of Novel Conjugated Schiff Bases

Corresponding Author(s) : Muhammad Yousaf

Abstract

Keywords

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