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Vol. 30 No. 10 (2018): Vol 30 Issue 10, 2018

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Synthesis and Antimicrobial Assay of Some Novel 4-Thiazolidinone Derivatives Possessing Benzofuran, Quinoline and Pyrazole Moieties

https://doi.org/10.14233/ajchem.2018.21522
M. Idrees
Department of Chemistry, Government Institute of Science, Nagpur-440 001, India
Y.G. Bodkhe
Department of Chemistry, Government Science College, Gadchiroli-442 605, India
N.J. Siddiqui
Department of Chemistry, Government Institute of Science, Nagpur-440 001, India

Corresponding Author(s) : M. Idrees

idreesshaikh.2009@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 10 (2018): Vol 30 Issue 10, 2018

Abstract

In this study, simple, easy and convenient syntheses of six novel 4-thiazolidinone derivatives (3a-f) bearing benzofuran, quinoline and pyrazole moieties have been described. In the first step, six different carbohydrazides (2a-f) were synthesized by reacting 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (2) with six different 2-(p-tolyloxy)quinoline-3-carbaldehyde (1a-f). Similarly, in second step, 5-(benzofuran-2-yl)-N¢-(2-(2-(p-tolyloxy) substituted quinolin-3-yl)-4-oxothiazolidin-3-yl)-1-phenyl-1H-pyrazole-3-carboxamide (3a-f) was prepared in excellent yield through the interaction of compounds 2a-f with thioglycolic acid in presence of anhydrous zinc chloride. Structural identifications of products 2a and 3a are reported on the basis of IR, 1H NMR, 13C NMR and mass spectra and the analytical data confirms the structure of title compounds. Further, these new products have been assayed for their antimicrobial screening against S. aureus and E. coli as the two selected bacterial strains and two fungi such as C. albicans and A. niger using paper disc diffusion method. Antimicrobial screening revealed that the compounds are good antibacterial agents but found to be inactive against fungi.

Keywords

Quinoline Carbohydrazides Thiazolidinone Pyrazole Antibacterial activity
Idrees, M., Bodkhe, Y., & Siddiqui, N. (2018). Synthesis and Antimicrobial Assay of Some Novel 4-Thiazolidinone Derivatives Possessing Benzofuran, Quinoline and Pyrazole Moieties. Asian Journal of Chemistry, 30(10), 2361–2364. https://doi.org/10.14233/ajchem.2018.21522
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