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Vol. 26 No. 18 (2014): Vol 26 Issue 18

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Modulation of Aggregation Behaviour of Amphiphlic Drug and Surfactant Mixture under the Influence of Neutral Polymer

https://doi.org/10.14233/ajchem.2014.16488
Naved Azum
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Malik Abdul Rub
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Abdullah M. Asiri
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Aftab Aslam Parwaz Khan
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Anish Khan
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Sher Bahadar Khan
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Mohammed M. Rahman
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

Corresponding Author(s) : Naved Azum

navedazum@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18

Abstract

The interaction of non-ionic surfactant, Triton X-114 (TX-114) with amphiphilic drug i.e., imipramine hydrochloride (IMP) has been investigated by surface tension measurement in the absence and presence of hydroxypropyl methylcellulose (HPMC) polymer. In the presence of the HPMC the plots of surface tension versus concentration of TX-114 + IMP mixed system show interesting features (i.e., two break points). The two break points attributed to the occurrence of two kind of aggregation process. In the presence of HPMC, the first break is close to that in pure water, can be regarded as critical aggregation concentration (cac), whereas second one is 2-3 times higher than the first one and can be attributed to the polymer bound micelles. The interfacial and bulk behavior was investigated using various theoretical models of Clint, Rosen, Rubingh etc. Synergism was observed in all binary combinations in the micelle and at the interface with or without the HPMC. Various thermodynamic parameters have been calculated with the help of regular solution theory (RST) and pseudo phase model for micellization.

Keywords

Imipramine hydrochloride Hydroxypropyl methylcellulose Critical aggregation concentration Critical micelle concentration
Azum, N., Abdul Rub, M., M. Asiri, A., Aslam Parwaz Khan, A., Khan, A., Bahadar Khan, S., & M. Rahman, M. (2014). Modulation of Aggregation Behaviour of Amphiphlic Drug and Surfactant Mixture under the Influence of Neutral Polymer. Asian Journal of Chemistry, 26(18), 6023–6028. https://doi.org/10.14233/ajchem.2014.16488
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