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Vol. 26 No. 18 (2014): Vol 26 Issue 18

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An Efficient and Green Synthesis of Benzylidene-2-N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine Derivatives and their Antibacterial Activity Evaluation

https://doi.org/10.14233/ajchem.2014.16333
V. Anitha Rani
Department of Chemistry, Institute of Aeronautical Engineering, Dundigal (V), Quthbullapur (Mandal), Hyderabad-500 043, India
Y. Bharathi Kumari
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad-500 085, India

Corresponding Author(s) : V. Anitha Rani

anitha1810@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 18 (2014): Vol 26 Issue 18

Abstract

An efficient and green synthesis of (Z)-3-allkyl-5(benzylidene/substituted benzylidene)-2N- (carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine derivatives have been developed in good yields and tested for their antibacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus subtillis compared to standard drug streptomycin.

Keywords

Green synthesis 1,2,4-Triazine derivatives Antibacterial activity
Anitha Rani, V., & Bharathi Kumari, Y. (2014). An Efficient and Green Synthesis of Benzylidene-2-N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine Derivatives and their Antibacterial Activity Evaluation. Asian Journal of Chemistry, 26(18), 5931–5934. https://doi.org/10.14233/ajchem.2014.16333
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