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Vol. 26 No. 17 (2014): Vol 26 Issue 17

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A Simple Method to Fabricate Hemocompatible Coating by Crosslinkable Biomimetic Bipolymer

https://doi.org/10.14233/ajchem.2014.18197
Shan Yang
School of Materials Science and Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China ; Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, P.R. China ; College of Chemistry and Life Science, Weinan Normal University, Weinan 714099, P.R. China
Yanbing Wang
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, P.R. China
Ming Gong
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, P.R. China ; School of Chemistry and Chemical Engineering, Xi’an University of Science and Technology, Xi’an 710054, P.R. China
Yongkuan Gong
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, P.R. China

Corresponding Author(s) : Shan Yang

yss12041981@163.com

Asian Journal of Chemistry, Vol. 26 No. 17 (2014): Vol 26 Issue 17

Abstract

2-Methacryloyloxyethyl phosphorylcholine (MPC) and 3-(methacryloyloxy) propyltrimethoxysilane (TSMA) were used to synthesize the crosslinkable biomimetic copolymer PMT by the free radical copolymerization. The PMT82, the molar ratio 8:2 of MPC and TSMA in copolymer, was chosen as the coating material. It was dissolved in methanol and dip-coated on cover glass in order to obtain the biomimetic coating. The PMT coatings were fixed onto the glass substrate through heating in moisture atmosphere. The surface hydrophilicity, elemental composition, blood compatibility of the coatings were measured by dynamic contact angles, X-ray photoelectron spectroscopy, platelet adhesion and protein adsorption in vitro, respectively. The results indicated that the polymer coatings have been successfully immobilized onto the surface of cover glass, which improved the surface hydrophilicity of cover glass and granted it excellent blood compatibility. The biopolymer PMT will be a promising coating material, and the simple surface modification method will be useful in biomaterials field.

Keywords

Phosphorylcholine Surface modification Biomimetic coating Hemocompatibility Crosslinkable polymer
Yang, S., Wang, Y., Gong, M., & Gong, Y. (2014). A Simple Method to Fabricate Hemocompatible Coating by Crosslinkable Biomimetic Bipolymer. Asian Journal of Chemistry, 26(17), 5745–5749. https://doi.org/10.14233/ajchem.2014.18197
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References
  1. J.P. Xu, J. Ji, W.D. Chen, D.Z. Fan, F.Y. Sun and J.C. Shen, Chem. J. Chinese Univ., 25, 188 (2004).
  2. W.G. Pitt, K. Park and S.L. Cooper, J. Colloid Interf. Sci., 111, 343 (1986); doi:10.1016/0021-9797(86)90039-1.
  3. W. Wei and W.Z. Cheng, Chinese Polym. Bull., 5, 39 (2004).
  4. J. Ji, L.X. Feng and J.C. Shen, Chem. J. Chinese Univ., 23, 2369 (2002).
  5. M. Gong, S. Yang, S.P. Zhang and Y.K. Gong, Prog. Chem., 20, 1628 (2008).
  6. K. Ishihara, H. Nomura, T. Mihara, K. Kurita, Y. Iwasaki and N. Nakabayashi, J. Biomed. Mater. Res., 39, 323 (1998); doi:10.1002/(SICI)1097-4636(199802)39:2<323::AID-JBM21>3.0.CO;2-C.
  7. N. Morimoto, A. Watanabe, Y. Iwasaki, K. Akiyoshi and K. Ishihara, Biomaterials, 25, 5353 (2004); doi:10.1016/j.biomaterials.2003.12.047.
  8. M. Gong, S. Yang, J.N. Ma, S.P. Zhang, F.M. Winnik and Y.K. Gong, Appl. Surf. Sci., 255, 555 (2008); doi:10.1016/j.apsusc.2008.06.148.
  9. S. Yang, Z.X. Yang and Y.K. Gong, J. Funct. Mater. Devices, 18, 371 (2012).
  10. J.A. Lv, J.N. Ma, P.B. Huangfu, S. Yang and Y.K. Gong, Appl. Surf. Sci., 255, 498 (2008); doi:10.1016/j.apsusc.2008.06.149.
  11. M. Gong, Y. Dang, Y.B. Wang, S. Yang, F.M. Winnik and Y.K. Gong, Soft Matter, 9, 4501 (2013); doi:10.1039/c3sm00086a.
  12. P.B. Huangfu, M. Gong, C.F. Zhang, S. Yang, J. Zhao and Y.K. Gong, Colloids Surf. B Biointerfaces, 71, 268 (2009); doi:10.1016/j.colsurfb.2009.02.014.
  13. Y. Iwasaki, A. Matsumoto and S. Yusa, ACS Appl. Mater. Interfaces, 4, 3254 (2012); doi:10.1021/am3006065.
  14. K. Fujii, H.N. Matsumoto, Y. Koyama, Y. Iwasaki, K. Ishihara and K. Takakuda, J. Vet. Med. Sci., 70, 167 (2008); doi:10.1292/jvms.70.167.
  15. L. Zhu, Q. Jin, J. Xu, J. Ji and J. Shen, J. Appl. Polym. Sci., 113, 351 (2009); doi:10.1002/app.29750.
  16. H.F. Yu, Y.C. Zhao and J. Wang, J. Funct. Mater., 42, 1265 (2011).
  17. T. Moro, H. Kawaguchi, K. Ishihara, M. Kyomoto, T. Karita, H. Ito, K. Nakamura and Y. Takatori, Biomaterials, 30, 2995 (2009); doi:10.1016/j.biomaterials.2009.02.020.
  18. Y.B. Wang, M. Gong, S. Yang, K. Nakashima and Y.K. Gong, J. Membr. Sci., 452, 29 (2014); doi:10.1016/j.memsci.2013.10.032.
  19. Y.K. Gong and F.M. Winnik, Acta Chim. Sin., 63, 643 (2005).
  20. S. Yang, Y.B. Wang, M.M. Zong, M. Gong, J.N. Ma and Y.K. Gong, Chem. J. Chinese Univ., 33, 1579 (2012).
  21. (a) Y. Yao, K. Fukazawa, N. Huang and K. Ishihara, Colloid Surf. B, 88, 215 (2011); doi:10.1016/j.colsurfb.2011.06.034; (b) Y. Yao, K. Fukazawa, W. Ma, K. Ishihara and N. Huang, Appl. Surf. Sci., 258, 5418 (2012); doi:10.1016/j.apsusc.2012.02.027.
  22. Y.K. Gong, L.P. Liu and P.B. Messersmith, Macromol. Biosci., 12, 979 (2012); doi:10.1002/mabi.201200074.
  23. E.E. Stroganova, N.Y. Mikhailenko and O.A. Moroz, Glass Ceramics, 60, 315 (2003); doi:10.1023/B:GLAC.0000008235.49161.32.
  24. Q. Chen, J.A. Roether and A.R. Boccaccini, in eds.: N. Ashammakhi, R. Reis and F. Chiellini, Tissue Engineering Scaffolds from Bioactive Glass and Composite Materials; In: Topics in Tissue Engineering, Vol. 4, Chap. 6, pp. 3-27 (2008).
  25. K. Ishihara, T. Ueda and N. Nakabayashi, Polym. J., 22, 355 (1990); doi:10.1295/polymj.22.355.
  26. L. Cen, K.G. Neoh, Y. Li and E.T. Kang, Biomacromolecules, 5, 2238 (2004); doi:10.1021/bm040048v.
  27. Y. Inoue, J. Watanabe and K. Ishihara, J. Colloid Interf. Sci., 274, 465 (2004); doi:10.1016/j.jcis.2004.02.067.
  28. S. Yang, Doctoral Dissertation, Synthesis and Application of Biomembrane Mimetic Polymers, Northwest University, China (2009).
  29. Z.M. Yang, Tissue Engineering, Chemical Industry Press, Beijing, P.R. China, vol. 12, p. 152 (2002).
  30. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson and D.C. Klenk, Anal. Biochem., 150, 76 (1985); doi:10.1016/0003-2697(85)90442-7.
  31. K. Kaladhar and C.P. Sharma, Langmuir, 20, 11115 (2004); doi:10.1021/la048644y.
  32. Y.M. Chen, M. Tanaka, J.P. Gong, K. Yasuda, S. Yamamoto, M. Shimomura and Y. Osada, Biomaterials, 28, 1752 (2007); doi:10.1016/j.biomaterials.2006.12.005.
  33. X.C. Zhang, W. Zhong, W.Z. Cheng and G.Q. Du, Chinese J. Biomed. Eng., 25, 92 (2006).
  34. A.L. Lewis, P.D. Hughes, L.C. Kirkwood, S.W. Leppard, R.P. Redman, L.A. Tolhurst and P.W. Stratford, Biomaterials, 21, 1847 (2000); doi:10.1016/S0142-9612(00)00055-7.
  35. S. Yang and Y.K. Gong, J. Northwest Univ., 41, 821 (2011).
  36. T. Goda, T. Konno, M. Takai, T. Moro and K. Ishihara, Biomaterials, 27, 5151 (2006); doi:10.1016/j.biomaterials.2006.05.046.
  37. J.M. Gibbins, J. Cell Sci., 117, 3415 (2004); doi:10.1242/jcs.01325.
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