Synthesis, Characterization and Antimicrobial Activity of Cu(II), Ni(II), Co(II), Zn(II) Complexes with Isonicotinoylhydrazone-4-benzyloxybenzaldehyde

Abstract

The complexes of Co(II), Ni(II), Cu(II) and Zn(II) with isonicotinoylhydrazone- 4-benzyloxybenzaldehyde (INHBBA) are reported. The complexes have been characterized by analytical data, IR, UV-Vis, NMR spectra, magnetic susceptibility, thermal analysis and for the Cu(II) complex the ESR spectrum has been registered. The biological activity of these complexes were investigated against Staphylococcus aureus, Escherichia coli and Klebssiella pneumoniae bacteria. The experimental data suggest a stoichiometry of 1:2 (metal:ligand) for all these complexes. The INHBBA ligand is coordinated bidentate by the C=O amide oxygen and the azomethine nitrogen in the complexes of Cu(II), Ni(II), Co(II) and monodentate by the nitrogen of the pyridinic ring in the complex of Zn(II).