Green Solid Oxidation of Sulfides to Sulfones Using Oxone and Biological Evaluation

Abstract

A ‘green’ highly selective oxidation of organic sulphides, N-substituted- β-(4-phenyl-2-thiazolyl)thio-alkyl/aryl propionamides (I) to the corresponding sulfones (II) was developed employing solid-state condition by using oxone. The synthesized compounds were confirmed by using elemental analysis and spectral data. These synthesized compounds were tested for their antibacterial and antifungal activities. None of them were found to possess any promising activity. This oxidation system is found clean, safe, operationally simple and environmentally friendly and meets the needs of contemporary ‘Green Chemistry’ and is suitable for practical synthesis.