Synthesis of Some Novel 2,4-Thiazolidinedione Derivatives and Their Biological Screening as Antidiabetic Agents

Abstract

Six derivatives of 2,4-thiazolidinedione having dialkyl amine appendage at N-3 position were synthesized and their antidiabetic activity were evaluated. All derivatives were synthesized by the reaction of 2,4-thiazolidinedione with different aldehydes, which further react with different dialkylamine. All derivatives were evaluated for their glucose lowering capability in dexamethasone induced diabetic rat.