Development and Validation of RP-HPLC Method for Estimation of Zolmitriptan in Tablet Dosage Forms
D. Gowri Sankar
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
A. Nagesh Babu
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
A. Rajeswari
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
M. Vamsi Krishna
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
Corresponding Author(s) : D. Gowri Sankar
gowrisankar97@rediffmail.com
Asian Journal of Chemistry,
Vol. 21 No. 7 (2009): Vol 21 Issue 7
A rapid, simple and precise reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the estimation of zolmitriptan in tablets. The quantification was carried out using a X-Terra RP C-18 column (150 mm × 4.6 mm i.d., 5 μm particle size) in isocratic mode with mobile phase comprising of phosphate buffer, acetonitrile and methanol in the ratio of 65:15:20 (v/v) at a flow rate of 1 mL/min. The eluent was monitored at 225 nm. The retention time of the drug was 4.278 min. The calibration curve was linear in the concentration range of 5-70 μg/mL and per cent recovery ranged from 99.8-100.08.
Keywords
ZolmitriptanRP-HPLCTablets
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Gowri Sankar, D., Nagesh Babu, A., Rajeswari, A., & Vamsi Krishna, M. (2010). Development and Validation of RP-HPLC Method for Estimation of Zolmitriptan in Tablet Dosage Forms. Asian Journal of Chemistry, 21(7), 5019–5022. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18268
