RP-HPLC Determination of Voriconazole in Pure and Pharmaceutical Dosage Forms
D. Gowri Sankar
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
A. Nagesh Babu
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
A. Rajeswari
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
M. Vamsi Krishna
Department of Pharmaceutical Analysis and Quality Assurance, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
Corresponding Author(s) : D. Gowri Sankar
gowrisankar97@rediffmail.com
Asian Journal of Chemistry,
Vol. 21 No. 7 (2009): Vol 21 Issue 7
A reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of voriconazole in bulk and pharmaceutical formulations. The quantification was carried out using a RP-C-18 Hypersil BDS column (250 mm × 4.6 mm i.d., 5 μ particle size) in isocratic mode with mobile phase comprising water, acetonitrile and methanol in the ratio of 50:25:25 v/v. The mobile phase was pumped at a rate of 1.5 mL/min and detection was carried out at 256 nm. The linearity was found to be in the range of 20-400 μg/mL. The proposed method was statistically evaluated and can be applied for routine quality control analysis of voriconazole in tablets.
Keywords
VoriconazoleRP-HPLCTablets
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Gowri Sankar, D., Nagesh Babu, A., Rajeswari, A., & Vamsi Krishna, M. (2010). RP-HPLC Determination of Voriconazole in Pure and Pharmaceutical Dosage Forms. Asian Journal of Chemistry, 21(7), 5015–5018. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18267
