Quantitative Structure-Pharmacokinetic Relationship Modelling on Quinolone Drugs: Serum Protein Binding
Corresponding Author(s) : BHUPINDER SINGH
bsbhoop@yahoo.com; ypsingla@yahoo.co.in
Asian Journal of Chemistry,
Vol. 21 No. 6 (2009): Vol 21 Issue 6
Abstract
This study was conducted to investigate quantitative structure pharmacokinetic relationships (QSPR) for serum protein binding (% SPB) in humans amongst 28 quinolone drugs employing extra thermodynamic multilinear regressions analysis (MLRA) approaches. The overall predictability was found to be quite high (R2 = 0.8699, F = 19.10, S2 = 93.79, Q2 = 0.6675, p < 0.001).
Keywords
A QSPR
ADME
Pharmacokinetics
Descriptors
PAUL, Y., S. DHAKE, A., & SINGH, B. (2010). Quantitative Structure-Pharmacokinetic Relationship Modelling on Quinolone Drugs: Serum Protein Binding. Asian Journal of Chemistry, 21(6), 4728–4732. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18222
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