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Vol. 21 No. 6 (2009): Vol 21 Issue 6

Quantitative Structure-Pharmacokinetic Relationship Modelling on Quinolone Drugs: Serum Protein Binding

YASH PAUL
Pharmaceutics and Pharmacokinetics, University Institute of Pharmaceutical Sciences (UGC Centre of Advance Studies), Panjab University, Sector-14, Chandigarh-160 014, India
AVINASH S. DHAKE
Pharmaceutics and Pharmacokinetics, University Institute of Pharmaceutical Sciences (UGC Centre of Advance Studies), Panjab University, Sector-14, Chandigarh-160 014, India
BHUPINDER SINGH
Pharmaceutics and Pharmacokinetics, University Institute of Pharmaceutical Sciences (UGC Centre of Advance Studies), Panjab University, Sector-14, Chandigarh-160 014, India

Corresponding Author(s) : BHUPINDER SINGH

bsbhoop@yahoo.com; ypsingla@yahoo.co.in

Asian Journal of Chemistry, Vol. 21 No. 6 (2009): Vol 21 Issue 6

Abstract

This study was conducted to investigate quantitative structure pharmacokinetic relationships (QSPR) for serum protein binding (% SPB) in humans amongst 28 quinolone drugs employing extra thermodynamic multilinear regressions analysis (MLRA) approaches. The overall predictability was found to be quite high (R2 = 0.8699, F = 19.10, S2 = 93.79, Q2 = 0.6675, p < 0.001).

Keywords

A QSPR ADME Pharmacokinetics Descriptors
(1)
PAUL, Y.; S. DHAKE, A.; SINGH, B. Quantitative Structure-Pharmacokinetic Relationship Modelling on Quinolone Drugs: Serum Protein Binding. ajc 2010, 21, 4728-4732.
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