Synthesis and Evaluation of New 3-Substituted[3,4-dihydro pyrimidinones]indolin-2-ones for Antioxidant Activity

Abstract

New 3-substituted[3,4-dihydropyrimidinones]indolin-2-ones have been synthesized and tested for antioxidant activity by UV spectrophotometer and HPLC method. Among them compounds C₁₆, C₁₅, C₁₄, C₁₃ and C₁₂ exhibited higher antioxidant activity. However, these antioxidant activities are lower than ascorbic acid. Antioxidant activities are performed both UV-Vis spectrometer and reverse phase HPLC methods, both the methods were compared and found 2 to 5 % variation were observed. HPLC method is more sensitive and suitable for the said compounds than UV-Vis spectrometer.