Development of a Scalable Process for a Key Intermediate of Rocuronium Bromide: A Neuromuscular Blocking Agent¦
Corresponding Author(s) : JAYDEEPKUMAR LILAKAR
jaydeepkumar@drreddys.com
Asian Journal of Chemistry,
Vol. 21 No. 6 (2009): Vol 21 Issue 6
Abstract
Rocuronium bromide 1 is an amino steroid non-depolarizing neuro muscular blocker or muscle relaxant used in modern anesthesia. An economical process has been developed for large-scale synthesis of key intermediate diepoxide 6 of rocuronium bromide.
Keywords
Epoxidation
(3b, 5a)-3-tosyloxy-androstan- 17-one,5a-androst-2-en-17-one,2a,3a,16a,17a-diepoxy-5aandrostan- 17b-yl-aetate
Rocuronium bromide
SRINIVASAN, N., T. MATHAD, V., HIMABINDU, V., & LILAKAR, J. (2010). Development of a Scalable Process for a Key Intermediate of Rocuronium Bromide: A Neuromuscular Blocking Agent¦. Asian Journal of Chemistry, 21(6), 4399–4403. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18178
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