Microbial Transformation of Prochiral Ketones Using Rhizopus arrhizus
Corresponding Author(s) : RAJESHRI S. SALUNKHE
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Asian Journal of Chemistry,
Vol. 21 No. 6 (2009): Vol 21 Issue 6
Abstract
The various species of Rhizopus arrhizus have been used for microbial transformations of p-chloro, p-methyl and p-methoxy propiophenone to synthesize corresponding enantiomerically pure (S) alcohols in 70- 90 % ee. In a screening of various species of Rhizopus arrhizus for enantioselective reduction of propiophenone derivatives, Rhizopus arrhizus NCIM-878 showed high activity for reduction of above prochiral ketones and it efficiently hydrolyzes the racemic acetate of p-methoxy propiophenone to corresponding (R) alcohol.
Keywords
Biotransformations
Transformation
Prochiral ketones
Rhizopus arrhizus
Bioreduction
Carbinols
R. SALOKHE, P., & S. SALUNKHE, R. (2010). Microbial Transformation of Prochiral Ketones Using Rhizopus arrhizus. Asian Journal of Chemistry, 21(6), 4333–4338. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/18170
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