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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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Synthesis, Characterization and Antimycobacterial Activity of Phenanthrenequinone Thiosemicarbazones and their Ruthenium and Zinc Complexes

https://doi.org/10.14233/ajchem.2021.23127
Ashok K. Singh
Department of Chemistry, University of Lucknow, Lucknow-226007, India
Shailendra K. Singh
Department of Chemistry, University of Lucknow, Lucknow-226007, India
Kavita Dhariyal
Department of Chemistry, University of Lucknow, Lucknow-226007, India
Ram Kumar
Microbiology Division, CSIR-Central Drug Research Institute, Sitapur Road, Lucknow-226031, India
Amarendra Kumar
Department of Chemistry, University of Lucknow, Lucknow-226007, India
Sudheer K. Singh
Microbiology Division, CSIR-Central Drug Research Institute, Sitapur Road, Lucknow-226031, India

Corresponding Author(s) : Ashok K. Singh

singhaks3@rediffmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

The substituted phenanthrenequinone thiosemicarbazones (HL1, HL2 and HL3), and their metal complexes (M = Ru(II) or Zn(II); SM1, SM2, SM3 and SM4) were synthesized and characterized by FT-IR, 1H & 13C NMR and ESI-MS. The spectral data IR, 1H & 13C NMR and ESI-MS indicates two tridentate ligands coordinating in the form of an octahedral geometry. The gas phase geometry of all the zinc(II) and ruthenium(II) complexes was carried by using density functional theory (DFT). The antimycobacterial susceptibility testing at 100 μM of the complexes using resazurin microtiter plate assay resulted in growth inhibition. Complexes SM2, SM3 and SM4 showed good antimycobacterial activity at 100 μM concentration by using rifampicin as inhibition control.

Keywords

Phenanthrenequinone Thiosemicarbazones Ruthenium complexes Zinc complexes Antimycobacterial Rifampicin
K. Singh, A., K. Singh, S., Dhariyal, K., Kumar, R., Kumar, A., & K. Singh, S. (2021). Synthesis, Characterization and Antimycobacterial Activity of Phenanthrenequinone Thiosemicarbazones and their Ruthenium and Zinc Complexes. Asian Journal of Chemistry, 33(5), 983–988. https://doi.org/10.14233/ajchem.2021.23127
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