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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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Synthesis and Antimicrobial Activity of Cyclic Dithiocarbamates Employing Triton-B/CS2 System

https://doi.org/10.14233/ajchem.2021.23173
Rishi Kumar Vishnoi
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India
Sangeeta Bajpai
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India
Devdutt Chaturvedi
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India
Manisha Shukla
Department of Chemistry, Babu Banarasi Das National Institute of Technology & Management, Lucknow-227105, India
Ram Kishore
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India
Nitin Srivastava
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India

Corresponding Author(s) : Sangeeta Bajpai

sbajpai1@amity.edu

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

An efficient and green methodology to synthesize cyclic dithiocarbamates (compounds 1-11) was developed by reaction of primary amines, CS2 and 1,2-dibromoethane or 1,4-dibromobutane, catalyzed by Triton-B (as PTC)/CS2 system. Mass spectroscopy, elemental analysis and 1H NMR are used for characterization of the synthesized compounds (1-11). This effectual green tactics give good yield of product which entails mild conditions. Compounds (1-11) were found to possess in vitro antimicrobial activities against the pathogenic bacterial and fungal strain. The microbial strains used to screen activities are Escherichia coli, Staphylococcus aureus and Candida albicans.

Keywords

Primary amine Dithiocarbamates Dihaloalkane Triton-B Biological activities
Kumar Vishnoi, R., Bajpai, S., Chaturvedi, D., Shukla, M., Kishore, R., & Srivastava, N. (2021). Synthesis and Antimicrobial Activity of Cyclic Dithiocarbamates Employing Triton-B/CS2 System. Asian Journal of Chemistry, 33(5), 1133–1136. https://doi.org/10.14233/ajchem.2021.23173
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