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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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Synthesis, in vitro Antimicrobial Evaluation, Molecular Docking Studies and ADME Prediction of Furan-2-yl-Morpholinophenylpyrimidine Derivatives

https://doi.org/10.14233/ajchem.2021.23148
M.R. Ezhilarasi
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore-641021, India
A.B. Senthieel Khumar
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore-641021, India
P. Elavarasan
Department of Chemical Engineering, Annamalai University, Annamalai Nagar, Chidambaram-608002, India

Corresponding Author(s) : M.R. Ezhilarasi

mrezhilarasi@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

A new series of novel 4-(furan-2-yl)-6-(4-morpholinophenyl)pyrimidine-amines (4a-c) were synthesized and characterized by elemental analysis and spectral analysis like IR, 1D 1H & 13C NMR. The synthesized compounds 4a-c were evaluated for their biological studies. The zone of inhibitions were examined for synthesized compounds 4a-c besides the identical set of microbial strains, especially that compound 4a against S. aureus, S. pyogenes, E. coli, compound 4b against P. aeruginosa has excellent antibacterial activity. Compound 4c shows good inhibition against C. albicans. Also in silico molecular docking and ADME predictions were carried for all the compounds. The docking studies were examined by two different proteins like 1UAG protein and 1OQA protein. in silico docking provides of the compounds have good docking score compared with the standard. In the ADME predictions all the compounds were met criteria. The synthesized compounds all of them obeyed the drug-likeness properties.

Keywords

Antimicrobial activity Molecular docking 4′-Morpholino acetophenone
Ezhilarasi, M., Senthieel Khumar, A., & Elavarasan, P. (2021). Synthesis, in vitro Antimicrobial Evaluation, Molecular Docking Studies and ADME Prediction of Furan-2-yl-Morpholinophenylpyrimidine Derivatives. Asian Journal of Chemistry, 33(5), 1090–1098. https://doi.org/10.14233/ajchem.2021.23148
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