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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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Interaction of Midazolam with Glassy Carbon Supported Lipid Membrane in the Presence and Absence of Marker Ions

https://doi.org/10.14233/ajchem.2021.23109
M. Padmapriya
Department of Chemistry, Sri Vasavi College, Erode-638316, India
K. Parvathi
Department of Chemistry, L.R.G. Government Arts College for Women, Tirupur-641604, India
S. Rameshkumar
Department of Chemistry, Sri Vasavi College, Erode-638316, India

Corresponding Author(s) : S. Rameshkumar

srksvc2016@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

A biomimetic membrane was formed on the surface of electrochemically activated glassy carbon electrode in NaCl bath solutions. The variation of electrochemical properties of solid supported bilayer lipid membrane (s-BLM) with NaCl concentration in the bath solutions in the presence and absence of ferri/ferrocyanide marker ions was discussed using electrochemical impedance spectroscopy. The extent of pore formation on the s-BLM surface was discussed using bode phase diagram. The electrochemical impedance studies show that the partition of midazolam into the s-BLM strongly depends on Cl– ion concentration in the bath solutions. The variation of membrane capacitance with drug dose shows the ionized form of midazolam interaction with the surface of s-BLM while the neutral and ion pair forms get partitioned into the membrane. In the presence of marker ions, the membrane resistance increases with decrease in NaCl concentration in the bath solution. The cyclic voltammetric responses of marker ions for bare and drug doped s-BLMs in NaCl bath solutions were recorded and variation of redox peak currents with drug dose was discussed.

Keywords

Glassy carbon electrode Solid supported bilayer lipid membrane Cyclic voltammetry Drug-membrane interaction
Padmapriya, M., Parvathi, K., & Rameshkumar, S. (2021). Interaction of Midazolam with Glassy Carbon Supported Lipid Membrane in the Presence and Absence of Marker Ions. Asian Journal of Chemistry, 33(5), 994–1000. https://doi.org/10.14233/ajchem.2021.23109
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