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Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

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Imidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line

https://doi.org/10.14233/ajchem.2021.23078
Hari Sharan Adhikari
Institute of Engineering, Pashchimanchal Campus, Department of Applied Sciences, Tribhuvan University, Pokhara, Nepal
Aditya Garai
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012, India
Chetana Khanal
Central Department of Biotechnology, Tribhuvan University, Kathmandu, Nepal
Rameshwar Adhikari
Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, Kathmandu, Nepal ; Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal
Paras Nath Yadav
Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal

Corresponding Author(s) : Paras Nath Yadav

pnyadav219@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 5 (2021): Vol 33 Issue 5, 2021

Abstract

Chitosan oligosaccharide and high molecular weight crab shell chitosan were functionalized as imidazole-2-carboxaldehyde chitosan thiosemicarbazones and their copper(II) complexes were synthesized. The synthesized compounds were characterized by FT-IR, 13C NMR, EPR spectroscopy, powder X-ray diffraction (PXRD) analysis, elemental analysis and magnetic susceptibility measurements. The low molecular weight chitosan thiosemicarbazones showed higher in vitro inhibitory activity as studied by MTT assay against the tumorigenic epithelial Madin-Darby Canine Kidney (MDCK) cell line than the corresponding high molecular weight chitosan derivative. The antitumorigenic enhancement upon the complex formation was revealed by the better inhibitory activity of copper(II) chitosan thiosemicarbazone chelates.

Keywords

Antitumorigenic activity Chitosan thiosemicarbazones Imidazole-2-carboxaldehyde MDCK cell line
Sharan Adhikari, H., Garai, A., Khanal, C., Adhikari, R., & Nath Yadav, P. (2021). Imidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line. Asian Journal of Chemistry, 33(5), 969–976. https://doi.org/10.14233/ajchem.2021.23078
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