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An Efficient Suitable Synthesis for Pyrazole, Pyrimidine Derivatives and Biological Evaluation
Corresponding Author(s) : S. Syed Shafi
Asian Journal of Chemistry,
Vol. 33 No. 4 (2021): Vol 33 Issue 4
Abstract
Novel quinazoline derivatives were synthesized by reacting isatoic anhydride and 4-amino acetanilide to synthesize N-(4-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)acetamide which in turn reacted with substituted aromatic aldehydes to synthesize novel chalcones. The chalcones were allowed to react with hydrazine hydrochloride and guanidine to form pyrazoline and pyrimidine derivatives, respectively. The newly synthesized compounds were characterized by IR, NMR (1H, 13C), mass and elemental analysis. All the newly synthesized derivatives were screened for in vitro antimicrobial and antioxidant activities to evaluate their biological potency.
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- S.J. Gawandi, V.G. Desai and S.G. Shingade, Med. Chem. Res., 28, 267 (2019); https://doi.org/10.1007/s00044-018-2282-x
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- K.M. Pandya, A.H. Patel and P.S. Desai, Chem. Africa, 3, 89 (2020); https://doi.org/10.1007/s42250-019-00096-5
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- K. Divekar, S. Swamy, N. Kavitha, V. Murugan and M. Devgun, Res. J. Pharm. Technol., 3, 1039 (2010).
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References
S.J. Gawandi, V.G. Desai and S.G. Shingade, Med. Chem. Res., 28, 267 (2019); https://doi.org/10.1007/s00044-018-2282-x
N.M. Abunada, H.M. Hassaneen, N.G. Kandile and O.A. Miqdad,Molecules, 13, 1011 (2008); https://doi.org/10.3390/molecules13041011
A.F. Macarini, T.U.C. Sobrinho, G.W. Rizzi and R. Corrêa, Med. Chem. Res., 28, 1235 (2019); https://doi.org/10.1007/s00044-019-02368-8
K.L. Amole, I.A. Bello and A.O. Oyewale, Chem. Africa, 2, 47 (2019); https://doi.org/10.1007/s42250-019-00043-4
K.M. Pandya, A.H. Patel and P.S. Desai, Chem. Africa, 3, 89 (2020); https://doi.org/10.1007/s42250-019-00096-5
M.A. Munawar, M. Azad, H.L. Siddiqui and F.-U.-H. Nasim, J. Chinese Soc., 55, 394 (2008); https://doi.org/10.1002/jccs.200800058
E. Akbas and I. Berber, Eur. J. Med. Chem., 40, 401 (2005); https://doi.org/10.1016/j.ejmech.2004.12.001
K. Divekar, S. Swamy, N. Kavitha, V. Murugan and M. Devgun, Res. J. Pharm. Technol., 3, 1039 (2010).
V.M. Barot, S.A. Gandhi, A. Mahato and N.B. Mehta, Int. J. Sci. Res., 3, 2 (2013).
U. Muhammet, Y. Budak, M.B. Gurdere, F. Erturk, B. Yencilek, P.Taslimi and I. Gulcin, J. Metabolic Dis., 124, 61 (2018); https://doi.org/10.1080/13813455.2017.1360914
P.M. Siva Kumar, S.K. Geetha Babu and D. Mukesh, Chem. Pharm.Bull., 55, 44 (2007); https://doi.org/10.1248/cpb.55.44
A.S. Rao and V.B. Kanne, Int. J. Pharm. Tech. Res., 6, 1113 (2014).
P. Malhotra, S. Pattan and A.P. Nikalje, Int. J. Pharm. Pharm. Sci., 2,21 (2010).
S. Kumari, S.K. Paliwal and R. Chauhan, Curr. Bioact. Compd., 14, 39 (2018); https://doi.org/10.2174/1573407212666161101152735
Y. Rajendra Prasad, A. Lakshmana Rao, L. Prasoona, K. Murali and P.Ravi Kumar, Bioorg. Med. Chem. Lett., 15, 5030 (2005); https://doi.org/10.1016/j.bmcl.2005.08.040
S.K. Kumar, E. Hager, C. Pettit, H. Gurulingappa, N.E. Davidson and S.R. Khan, J. Med. Chem., 46, 2813 (2003); https://doi.org/10.1021/jm030213+
H.K. Hsieh, L.T. Tsao, J.P. Wang and C.-N. Lin, J. Pharm. Pharmacol., 52, 163 (2000); https://doi.org/10.1211/0022357001773814
A. Chugh, A. Kumar, A. Verma, S. Kumar and P. Kumar, Med. Chem. Res., 29, 1723 (2020); https://doi.org/10.1007/s00044-020-02604-6
N.S. Tibon, C.H. Ng and S.L. Cheong, Eur. J. Med. Chem., 188, 111983 (2020); https://doi.org/10.1016/j.ejmech.2019.111983
E.G. Tse, M. Korsik and M.H. Todd, Malar. J., 18, 93 (2019); https://doi.org/10.1186/s12936-019-2724-z
R.J. Ruch, S.-J. Cheng and J.E. Klaunig, Carcinogenesis, 10, 1003 (1989); https://doi.org/10.1093/carcin/10.6.1003